Tom Gilbertson's Lab Systems and circuit neuroscience of movement disorders

Research

My group investigates abnormal structure and function relationships in neural circuit disorders of the human brain. These include Parkinson’s disease, Essential Tremor and Dystonia. We study patients with using techniques developed from human neuroscience , including computational modeling of decision making, functional Magnetic Resonance Imaging, diffusion tensor imaging and event related EEG.

A particular focus is applying quanitatitive imaging analysis methods to two major research themes:

  • improving outcomes from focused ultrasound lesion therapy in Essential Tremor and Parkinson’s disease
  • using focused ultrasound neuromodulation to identify new targets for non-motor symptoms in Parkinson’s Disease such as apathy.
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Publications & Talks

Impaired value-based decision-making in Parkinson’s disease apathy. William Gilmour, Graeme Mackenzie, Mathias Feile, Louise Tayler-Grint, Szabolcs Suveges, Jennifer A Macfarlane, Angus D Macleod, Vicky Marshall, Iris Q Grunwald, J Douglas Steele, Tom Gilbertson

Mapping the thalamus’s role in reinforcement learning with Focused Ultrasound Thalamotomy

Pallidal neuromodulation of the explore/exploit trade-off in decision-making. Ana Luísa de A. Marcelino, Owen Gray, Bassam Al-Fatly, William Gilmour, J. Douglas Steele, Andrea A. Kühn, Tom Gilbertson

Brain targeting for focused ultrasound essential tremor ablation: proceedings from the 2023 Focused Ultrasound Foundation workshop. Chua, Melissa M. J., Suzanne LeBlang, Lauren Powlovich, Tom Gilbertson, Vibhor Krishna, Charles R. G. Guttmann, Matthew D. C. Eames, Frantz R. Poulsen, and G. Rees Cosgrove

Updates

New Website - February 25, 2025

Royal Society Summer Science Exhibition - December 20, 2024

Invited Talk at MRC Brain Network Dynamics Unit, University of Oxford - October 20, 2024